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| |
ALS
|
Healthy control
|
p
|
|---|
|
All
|
C9orf72+
|
C9orf72−
|
HC vs ALS
|
C9orf72 + vs non-C9orf72 −
|
|---|
|
N
|
12
|
3
|
9
|
5
|
–
|
–
|
|
%male
|
66.7
|
33.3
|
77.8
|
20
|
0.131a
|
0.236a
|
|
Age at sampling, mean ± SD (years)
|
68.1 ± 12.0
|
51.9 ± 15.6
|
65 ± 10.0
|
52.0 ± 14.8
|
0.113b
|
0.166b
|
|
Age at onset, mean ± SD (years)
|
59.7 ± 12.4
|
51.0 ± 15.6
|
62.6 ± 10.7
|
–
|
–
|
0.229b
|
|
% bulbar onset
|
50.0
|
66.7
|
44.4
|
–
|
–
|
0.545a
|
|
Disease progression rate, median [IQR]
|
0.53 [0.21–0.63]
|
0.62 [0.37–0.83]
|
0.51 [0.22–0.60]
|
–
|
–
|
0.782b
|
- ALS amyotrophic lateral sclerosis, HC healthy control, SD standard deviation, IQR interquartile range
- aFisher exact test. bKruskal–Wallis H test
